Thymosin Alpha 1

99%+ Purity USA Tested

Research Use Only. Not for Human or Veterinary Use

Thymosin Alpha-1 (Tα1): Immunomodulatory thymic peptide and T-cell activating cytokine inducer, CAS 62304-98-7, MW 3108.3 g/mol, ≥99% purity. Lyophilized powder for laboratory use.

$79.00

Peptide Name	Thymosin Alpha-1 (Tα1)
CAS Number	62304-98-7
Molecular Formula	C₁₂₉H₂₁₅N₃₃O₅₅
Molecular Weight	~3108.3 g/mol
Mechanism Class	Immunomodulatory thymic peptide (T-cell activator / TLR agonist)
Appearance	White lyophilized powder
Purity	≥99% (HPLC)
Storage	-20°C, desiccated, protected from light
Solubility	Soluble in sterile water

This product is not intended for human or animal use. For scientific research only.

VivePeptides provides detailed analytical results including High-Performance Liquid Chromatography (HPLC) and mass spectrometry data for all peptides. These reports confirm peptide purity, composition, and molecular accuracy, giving researchers full transparency and confidence in the materials used for their studies.

All VivePeptides products undergo independent third-party laboratory testing to verify identity, purity, and consistency. This additional layer of quality control ensures that each peptide meets strict research-grade standards before being made available for laboratory use.

VivePeptides peptides should be stored in a cool, dry environment and protected from light and moisture. Lyophilized peptides are best kept refrigerated or frozen until use to maintain stability. Once reconstituted for research purposes, peptides should be stored according to standard laboratory protocols, typically under refrigeration, and handled using proper aseptic techniques to preserve integrity throughout the study period.

OVERVIEW

What Is Thymosin Alpha 1 Peptide?

Thymosin Alpha 1 is a naturally occurring 28-amino acid peptide originally isolated from calf thymus tissue by Allan Goldstein and colleagues in 1977. It is derived from a larger precursor protein called prothymosin alpha and plays a central role in immune system development and regulation. The synthetic version, known as Thymalfasin, has been approved for clinical use in over 35 countries and is one of the most extensively studied immunomodulatory peptides in biomedical research.

As a research peptide, Thymosin Alpha 1 belongs to the class of thymic peptides that regulate T-cell maturation and adaptive immune function. Unlike many immunostimulatory compounds that broadly activate immune pathways, Thymosin Alpha 1 research has demonstrated a more nuanced effect, enhancing immune surveillance while simultaneously modulating inflammatory responses. This dual capability has made it a valuable tool in immunology research spanning infectious disease, oncology, and vaccine development.

Thymic Immunomodulator

Naturally occurring 28-amino-acid peptide derived from thymus tissue prothymosin alpha

≥99% HPLC Purity

Every batch verified via high-performance liquid chromatography

USA Tested & Verified

Third-party analytical testing performed in USA laboratories

RESEARCH

Thymosin Alpha 1 Mechanism of Action in Research

The Thymosin Alpha 1 mechanism of action has been the subject of extensive immunological research for nearly five decades. Studies have identified multiple pathways through which this peptide modulates immune function, distinguishing it from single-target immunostimulatory agents.

Toll-Like Receptor Activation

Research indicates that Thymosin Alpha 1 acts as an agonist for multiple Toll-like receptors (TLRs), including TLR2, TLR3, TLR4, TLR7, and TLR9. By binding to these pattern recognition receptors, Thymosin Alpha 1 activates downstream signaling cascades including MyD88, IRF3, NF-kB, and MAPK pathways. These pathways lead to the proliferation and activation of immune cells and the production of immune-related cytokines. Published research by Romani et al. (2007) demonstrated that TLR activation by Thymosin Alpha 1 plays a critical role in bridging innate and adaptive immune responses.

T-Cell Maturation and Differentiation

Thymosin Alpha 1 enhances the maturation and differentiation of T-cell precursors into functional CD4+ helper and CD8+ cytotoxic T cells. Research suggests this occurs through upregulation of T-cell surface markers and interleukin-2 (IL-2) receptor expression. Studies have shown that Thymosin Alpha 1 promotes the conversion of immature thymocytes into mature, functional T cells capable of mounting targeted immune responses (Goldstein et al., 2009).

Cytokine Network Modulation

Published studies demonstrate that Thymosin Alpha 1 stimulates the production of multiple cytokines including IL-2, IL-6, IL-10, IL-12, interferon-alpha (IFN-alpha), and interferon-gamma (IFN-gamma). Notably, research also shows a suppressive effect on pro-inflammatory cytokines including IL-1-beta and tumor necrosis factor-alpha (TNF-alpha), suggesting a balancing rather than purely stimulatory role in immune regulation.

COMPARISON

Thymosin Alpha 1 vs TB-500: Research Peptide Comparison

Both Thymosin Alpha 1 and TB-500 (Thymosin Beta-4 fragment) belong to the thymosin peptide family but serve fundamentally different roles in biological research. Thymosin Alpha 1 is primarily studied for immune modulation, while TB-500 is investigated for tissue biology and cell migration. Understanding these differences helps researchers select the appropriate compound for their specific laboratory protocols.

Feature	Thymosin Alpha 1	TB-500
Origin	Derived from thymus prothymosin alpha	Fragment of Thymosin Beta-4
Amino Acids	28	43
CAS Number	62304-98-7	77591-33-4
Molecular Weight	3108.3 Da	4963.5 Da
Primary Research Focus	Immune modulation and T-cell function	Cell migration and tissue biology
N-Terminal Modification	Acetylated (Ac-Ser)	None
Proposed Mechanism	TLR activation, T-cell maturation	Actin sequestration, cell motility
Research Volume	300+ published studies	50+ published studies

Both peptides belong to the thymosin family but represent distinct branches of thymosin research. Thymosin Alpha 1 is the primary compound for immunology studies, while TB-500 is preferred for tissue repair and cell migration research. VivePeptides offers both at research-grade purity from our USA-based facility.

RESEARCH STUDIES

Thymosin Alpha 1 Research Applications & Published Studies

Thymosin Alpha 1 research spans nearly five decades of published literature across immunology, infectious disease, and oncology. The following areas represent the most actively investigated applications. All references are to research contexts only.

Viral Hepatitis Research

Thymosin Alpha 1 has been extensively studied in hepatitis B and hepatitis C research. Mutchnick et al. (1991) published early findings on Thymosin Alpha 1’s effects in chronic hepatitis B models, and subsequent studies by Andreone et al. (1996) expanded this research to hepatitis C. Multiple clinical trials have examined Thymosin Alpha 1 as both a standalone agent and in combination with interferon therapy, contributing to its approval in over 35 countries for hepatitis-related applications.

Immune Function and Vaccine Enhancement Research

Research has investigated Thymosin Alpha 1’s potential as a vaccine adjuvant. Carraro et al. (2012) published findings demonstrating enhanced antibody responses when Thymosin Alpha 1 was co-administered with influenza vaccination in immunocompromised subjects. These studies have expanded the scope of Thymosin Alpha 1 research into vaccine development and immunosenescence.

Oncology Research Models

Published research has examined Thymosin Alpha 1 in oncology contexts. Garaci et al. (2012) reviewed its immunomodulatory properties in cancer models, demonstrating enhanced natural killer cell activity and CD8+ T-cell function. Studies have explored Thymosin Alpha 1 as an adjunctive agent alongside chemotherapy and immunotherapy protocols in preclinical and clinical research settings.

QUALITY ASSURANCE

Quality & Testing Standards

VivePeptides maintains rigorous quality control for every batch of Thymosin Alpha 1 peptide. Our commitment to research-grade purity ensures that laboratories receive consistent, reliable compounds for their investigations.

HPLC & Mass Spectrometry

Every batch of Thymosin Alpha 1 undergoes high-performance liquid chromatography (HPLC) and mass spectrometry analysis to confirm identity, purity, and molecular weight.

Third-Party Verified

All VivePeptides Thymosin Alpha 1 is independently verified through third-party analytical laboratories based in the USA. Testing documentation is available for every lot.

≥99% Purity Standard

Our Thymosin Alpha 1 consistently meets or exceeds ≥99% purity as determined by HPLC analysis, ensuring research-grade quality for laboratory applications.

FAQ

Frequently Asked Questions About Thymosin Alpha 1

What is Thymosin Alpha 1 used for in research?

Thymosin Alpha 1 is used in research settings to study immune system modulation, T-cell maturation, Toll-like receptor signaling, vaccine adjuvant effects, and cytokine network regulation. It is one of the most extensively published immunomodulatory peptides, with over 300 studies in the scientific literature. Thymosin Alpha 1 is sold for research use only.

What purity is VivePeptides Thymosin Alpha 1?

VivePeptides Thymosin Alpha 1 is manufactured to ≥99% purity as verified by HPLC analysis. Every batch is tested and verified through independent third-party USA-based laboratories to ensure consistent research-grade quality.

How should Thymosin Alpha 1 be stored?

Lyophilized Thymosin Alpha 1 should be stored at -20°C, protected from light and moisture. Once reconstituted, the solution should be stored at 2 to 8°C and used within 14 days for optimal stability. Avoid repeated freeze-thaw cycles.

What is the difference between Thymosin Alpha 1 and Thymosin Beta 4?

Thymosin Alpha 1 and Thymosin Beta 4 are distinct peptides from the thymosin family with different structures and research applications. Thymosin Alpha 1 is a 28-amino-acid peptide primarily studied for immune system modulation and T-cell function. Thymosin Beta 4 (and its fragment TB-500) is a 43-amino-acid peptide primarily studied for cell migration, actin regulation, and tissue biology. They share a thymic origin but operate through different mechanisms.

Is VivePeptides Thymosin Alpha 1 third-party tested?

Yes. Every lot of VivePeptides Thymosin Alpha 1 undergoes independent third-party testing at USA-based analytical laboratories. Testing includes HPLC purity analysis and mass spectrometry identity confirmation. Results are available upon request for qualified researchers.

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