NAD+

99%+ Purity USA Tested

Research Use Only. Not for Human or Veterinary Use

NAD⁺: Nicotinamide adenine dinucleotide (oxidized), CAS 53-84-9, MW 663.43 g/mol, ≥99% purity. Lyophilized powder for laboratory use.

$80.00

6 in stock

Compound Name	NAD⁺ (Nicotinamide Adenine Dinucleotide, oxidized form)
CAS Number	53-84-9
Molecular Formula	C₂₁H₂₇N₇O₁₄P₂
Molecular Weight	663.43 g/mol
Appearance	White to off-white lyophilized powder
Purity	≥99% (HPLC)
Storage	-20°C, desiccated, protected from light and moisture
Solubility	Soluble in water

This product is not intended for human or animal use. For scientific research only.

VivePeptides provides detailed analytical results including High-Performance Liquid Chromatography (HPLC) and mass spectrometry data for all peptides. These reports confirm peptide purity, composition, and molecular accuracy, giving researchers full transparency and confidence in the materials used for their studies.

VIEW COA

VivePeptides peptides should be stored in a cool, dry environment and protected from light and moisture. Lyophilized peptides are best kept refrigerated or frozen until use to maintain stability. Once reconstituted for research purposes, peptides should be stored according to standard laboratory protocols, typically under refrigeration, and handled using proper aseptic techniques to preserve integrity throughout the study period.

OVERVIEW

What Is NAD+?

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme present in every living cell and essential for fundamental biological processes including cellular energy metabolism, DNA repair, and gene expression regulation. NAD+ functions as a critical electron carrier in metabolic reactions, shuttling electrons between enzymes in glycolysis, the citric acid cycle, and oxidative phosphorylation. First described by Arthur Harden and William John Young in 1906, NAD+ is one of the most studied molecules in biochemistry.

NAD+ research has experienced a renaissance in the 21st century with the discovery of its role as a substrate for sirtuins, PARPs (poly-ADP-ribose polymerases), and CD38/CD157 ectoenzymes. NAD+ anti-aging research has been particularly influential, with studies documenting age-related NAD+ decline across multiple species and tissue types. NAD+ cellular energy research continues to reveal the central importance of this molecule in metabolic health, making it an indispensable tool for laboratories investigating bioenergetics, epigenetics, and aging biology. Researchers who buy NAD+ from VivePeptides receive ≥99% purity from a trusted USA supplier.

Essential Coenzyme

Dinucleotide cofactor central to cellular energy metabolism and redox biology

≥99% HPLC Purity

Every batch verified via high-performance liquid chromatography

USA Tested & Verified

Third-party analytical testing performed in USA laboratories

RESEARCH

NAD+ Mechanism of Action in Research

The NAD+ mechanism of action encompasses its dual roles as a redox cofactor and a signaling substrate. NAD+ research has identified multiple enzymatic pathways that consume and regenerate NAD+, creating a dynamic metabolic network.

Redox Metabolism and Electron Transfer

In its primary metabolic role, NAD+ serves as an electron acceptor in catabolic reactions. During glycolysis and the citric acid cycle, NAD+ is reduced to NADH by accepting hydride ions from metabolic intermediates. NADH then donates electrons to Complex I of the mitochondrial electron transport chain, driving ATP synthesis through oxidative phosphorylation. This NAD+/NADH redox cycling is essential for cellular energy production and represents a core focus of NAD+ cellular energy research.

Sirtuin Substrate and Epigenetic Regulation

NAD+ sirtuins research has emerged as one of the most active areas of NAD+ investigation. Sirtuins (SIRT1-7) are NAD+-dependent deacylase enzymes that remove acetyl and other acyl groups from proteins, consuming NAD+ in the process to produce nicotinamide and O-acetyl-ADP-ribose. Sirtuin activity directly depends on NAD+ availability, linking cellular metabolic status to epigenetic regulation, protein function, and stress response pathways (Imai & Guarente, Trends in Cell Biology, 2014).

DNA Repair Pathways (PARP Activity)

NAD+ is the essential substrate for poly-ADP-ribose polymerases (PARPs), enzymes that catalyze the addition of ADP-ribose polymers to proteins at sites of DNA damage. PARP-mediated DNA repair consumes substantial amounts of NAD+, and research indicates that excessive PARP activation can deplete cellular NAD+ pools. Understanding the competition between PARPs and sirtuins for available NAD+ is a major focus of current NAD+ research. —

COMPARISON

NAD+ vs NMN: Research Compound Comparison

NAD+ and NMN (nicotinamide mononucleotide) are both studied in the context of NAD+ metabolism research. NMN is a direct biosynthetic precursor to NAD+, and understanding their relationship is key for researchers in this field.

Feature	NAD+	NMN (Nicotinamide Mononucleotide)
CAS Number	53-84-9	1094-61-7
Molecular Weight	663.43 Da	334.22 Da
Role	Active coenzyme (end product)	Biosynthetic precursor to NAD+
Structure	Dinucleotide (NMN + AMP)	Mononucleotide
Cell Uptake	Large molecule, limited direct uptake	Smaller, studied for cellular uptake via SLC12A8
Enzymatic Function	Direct substrate for sirtuins, PARPs, CD38	Requires conversion to NAD+ via NMNAT enzymes
Research Applications	Direct enzyme studies, in vitro assays	Precursor biology, NAD+ boosting research
Stability	Requires careful storage, light-sensitive	Relatively more stable

NAD+ is the active form directly used as a coenzyme and enzyme substrate, making it essential for in vitro enzymatic assays and direct cellular studies. NMN is valuable for studying NAD+ biosynthesis pathways and cellular uptake mechanisms. VivePeptides NAD+ for sale is manufactured to ≥99% purity for reliable laboratory research.

RESEARCH STUDIES

NAD+ Research Applications & Published Studies

NAD+ research represents one of the most prolific fields in modern biochemistry, with thousands of published studies spanning metabolism, aging, and disease biology.

Aging and Longevity Research

NAD+ anti-aging research was catalyzed by the discovery that NAD+ levels decline with age in multiple tissues and species. Yoshino et al. (Cell Metabolism, 2011) published landmark findings on age-related NAD+ decline and its metabolic consequences. Subsequent studies by Gomes et al. (Cell, 2013) demonstrated that restoring NAD+ levels in aged mice reversed markers of mitochondrial dysfunction, generating significant interest in NAD+ biology across the geroscience research community.

Sirtuin Biology

NAD+ sirtuins research is extensively published, with key contributions from the laboratories of Leonard Guarente, David Sinclair, and others. Imai & Guarente (Trends in Cell Biology, 2014) published comprehensive reviews establishing the “NAD world” hypothesis — proposing that NAD+ availability coordinates systemic metabolic regulation through sirtuin activity across multiple tissues.

Metabolic and Mitochondrial Research

NAD+ cellular energy research encompasses studies of mitochondrial function, bioenergetics, and metabolic disease models. Published research has examined how NAD+ depletion affects electron transport chain function, mitochondrial membrane potential, and cellular ATP production. These studies utilize research-grade NAD+ in both cell-free enzymatic assays and cellular model systems.

QUALITY ASSURANCE

Quality & Testing Standards

HPLC & Mass Spectrometry

Every NAD+ batch undergoes HPLC and mass spectrometry analysis to confirm identity, purity, and molecular weight.

Third-Party Verified

All NAD+ is independently tested at third-party USA-based analytical laboratories with lot-specific documentation.

≥99% Purity Standard

VivePeptides NAD+ consistently meets or exceeds ≥99% purity as verified by HPLC for reliable research results.

FAQ

Frequently Asked Questions About NAD+

What is NAD+ used for in research?

NAD+ is used in research to study cellular energy metabolism, sirtuin biology, PARP-mediated DNA repair, redox biochemistry, mitochondrial function, and aging biology. It is an essential reagent for in vitro enzymatic assays and cellular metabolism studies. NAD+ is sold for research use only.

What purity is VivePeptides NAD+?

VivePeptides NAD+ is manufactured to ≥99% purity as verified by HPLC. Each batch is independently tested at USA-based analytical laboratories to confirm purity and identity.

How should NAD+ be stored?

Lyophilized NAD+ should be stored at -20°C, protected from light, moisture, and heat. NAD+ is hygroscopic and should be kept in a sealed container with desiccant. Reconstituted solutions should be used promptly and stored at 2–8°C.

What is the difference between NAD+ and NADH?

NAD+ is the oxidized form of nicotinamide adenine dinucleotide, while NADH is the reduced form carrying two additional electrons and a proton. These two forms cycle between oxidized and reduced states during metabolic reactions. NAD+ accepts electrons (is reduced to NADH) during catabolic reactions, and NADH donates electrons (is oxidized back to NAD+) at the electron transport chain.

Is VivePeptides NAD+ third-party tested?

Yes. Every lot of VivePeptides NAD+ undergoes independent third-party testing at USA-based laboratories, including HPLC purity analysis and mass spectrometry identity confirmation. Results are available for qualified researchers upon request.

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