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Cagrilintide research peptide vial

GLP-1 & Metabolic

Cagrilintide

99%+ Purity USA TestedResearch Use Only. Not for Human or Veterinary Use
10mg amylin receptor agonist research peptide
$85.00
1
Size
10mg
99%+ Purity
USA Lab Tested
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Specifications

Cagrilintide Technical Profile

Peptide Name: Cagrilintide (long-acting amylin analog) CAS Number: 1415456-99-3 Molecular Formula: C₁₉₄H₃₀₈N₅₄O₅₉ Molecular Weight: 4409.01 g/mol Mechanism Class: Long-acting amylin receptor agonist; non-selective agonist at AMY1-3 receptors and the calcitonin receptor, lipidated for extended half-life Appearance: White lyophilized powder Purity: ≥99% (HPLC) Storage: -20°C, desiccated, protected from light Solubility: Soluble in sterile or bacteriostatic water This product is not intended for human or animal use. For scientific research only.

OVERVIEW

What Is Cagrilintide?

Cagrilintide (development code AM833, CAS 1415456-99-3) is a long-acting synthetic analog of human amylin, supplied as a lyophilized powder for laboratory research. Amylin, also called islet amyloid polypeptide (IAPP), is a 37 residue hormone co-secreted with insulin from pancreatic beta cells, and it is one of the principal endogenous signals studied in models of meal termination, gastric motility, and postprandial glucagon regulation. Native human amylin is poorly suited to experimental work because it aggregates readily into amyloid fibrils and clears within minutes, which is the specific problem cagrilintide was engineered to solve.

Structurally, cagrilintide retains the 37 residue amylin backbone with substitutions at positions 14, 17, and 37 that suppress fibril formation and improve metabolic stability, plus an eicosanedioic (C20) fatty diacid attached through a gamma glutamic acid linker. That acyl chain drives reversible albumin binding in circulation, which slows renal clearance and extends the reported elimination half-life into the range of roughly 159 to 195 hours. The practical result for a research setting is a stable, soluble amylin receptor agonist with a duration of action measured in days rather than minutes. Researchers who buy cagrilintide from VivePeptides receive a lyophilized preparation at greater than or equal to 99% purity from a trusted USA supplier.

  • 01

    Long-Acting Amylin Analog

    37 residue amylin backbone with C20 diacid acylation for albumin binding and extended half-life

  • 02

    ≥99% HPLC Purity

    Every batch verified via high-performance liquid chromatography

  • 03

    USA Tested & Verified

    Third-party analytical testing performed in USA laboratories

RESEARCH

Cagrilintide Mechanism of Action in Research

The cagrilintide mechanism of action described in the literature is non-selective agonism across the amylin receptor family. Amylin receptors are not single proteins but heterodimers: a calcitonin receptor core paired with one of three receptor activity-modifying proteins, giving AMY1 (RAMP1), AMY2 (RAMP2), and AMY3 (RAMP3). Cagrilintide activates all three, and it retains activity at the calcitonin receptor itself. This broad profile distinguishes it from selective amylin analogs and is a recurring variable in comparative receptor pharmacology work (Kruse et al., Journal of Medicinal Chemistry, 2021).

01

AMY1-3 Receptor Agonism

Signals through calcitonin receptor and RAMP1, RAMP2, and RAMP3 heterodimers, which are densely expressed in the area postrema, nucleus tractus solitarius, and hypothalamus. These hindbrain and hypothalamic nodes are the standard anatomical focus of amylin signaling research.

02

Albumin-Mediated Protraction

The gamma glutamic acid linked C20 diacid binds serum albumin reversibly, creating a circulating depot that reduces glomerular filtration. Reported elimination half-life sits near 159 to 195 hours, which supports weekly-interval dosing schedules in preclinical protocols.

03

Anti-Fibrillation Substitutions

Position 14, 17, and 37 substitutions reduce the amyloidogenic behavior that makes native human amylin difficult to formulate and study. This is what allows the analog to be handled as a conventional aqueous research reagent.

COMPARISON

Cagrilintide vs Native Human Amylin: Research Compound Comparison

Cagrilintide

The most informative comparison for cagrilintide is against the endogenous hormone it was designed to replace in experimental systems. Native human amylin is the physiological reference ligand, but its aggregation kinetics and sub-hour half-life confound almost any study longer than an acute infusion. Cagrilintide preserves the receptor pharmacology while removing both liabilities, which is why it has largely displaced native amylin as the tool compound in chronic-exposure models.

Native Human Amylin

Amylin receptor signaling is also studied alongside incretin receptor signaling, since the two pathways converge on energy balance through partly separate routes: amylin acts prominently through hindbrain circuits governing meal size and gastric emptying, while incretin receptor agonists act substantially through hypothalamic and peripheral routes. Researchers investigating that intersection often run cagrilintide in parallel with a multi-receptor incretin agonist such as Vive GLP(R). Both are supplied here for research use only.

FeatureCagrilintideNative Human Amylin
CAS Number1415456-99-3106602-62-4
Molecular Weight≈4409 g/mol≈3903 g/mol
Structure37 residues, substituted at positions 14, 17, and 37, C20 diacid acylated37 residues, unmodified, C-terminal amide and 2-7 disulfide bridge
Elimination Half-LifeApproximately 159 to 195 hoursApproximately 13 minutes
Aggregation BehaviorSubstitutions suppress amyloid fibril formationHighly amyloidogenic, forms islet amyloid fibrils
Receptor ActivityNon-selective agonist at AMY1, AMY2, AMY3, and the calcitonin receptorEndogenous agonist at AMY1, AMY2, AMY3
Primary Research FocusChronic-exposure metabolic models, receptor pharmacology, weekly-interval protocolsAcute physiological reference ligand, islet amyloid and beta cell studies

RESEARCH STUDIES

Cagrilintide Research Applications & Published Studies

Published cagrilintide work spans medicinal chemistry, receptor pharmacology, and preclinical metabolic modeling. The foundational paper describing the design rationale, the acylation strategy, and the in vivo pharmacokinetic profile is Kruse and colleagues in the Journal of Medicinal Chemistry (2021), and it remains the standard citation for the analog's structure-activity work. Downstream literature has focused on amylin receptor signaling in hindbrain feeding circuits and on the combination pharmacology of amylin and incretin pathways in animal models.

Published Research

Receptor Pharmacology

Used as a long-acting probe to characterize AMY1-3 and calcitonin receptor activation, receptor selectivity profiling, and RAMP-dependent signaling bias in cell-based assays.

Published Research

Preclinical Metabolic Models

Applied in diet-induced obesity and energy-balance models to examine food intake, gastric emptying rate, and body composition endpoints over multi-week exposure windows.

Published Research

Combination Pathway Research

Studied in parallel with incretin receptor agonists to investigate whether amylin and incretin signaling produce additive or independent effects on energy homeostasis endpoints in animal models.

QUALITY ASSURANCE

Quality & Testing Standards

HPLC Verified ≥99%

Purity confirmed by reverse-phase high-performance liquid chromatography on every production batch.

Mass Spectrometry Confirmed

Molecular identity verified by mass spectrometry against the expected 4409 g/mol target mass.

Third-Party USA Laboratories

Independent analytical testing performed in United States laboratories, with certificates of analysis available.

FAQ

Frequently Asked Questions About Cagrilintide

What is cagrilintide?

Cagrilintide (development code AM833, CAS 1415456-99-3) is a long-acting synthetic analog of human amylin, a 37 residue hormone co-secreted with insulin from pancreatic beta cells. It carries substitutions at positions 14, 17, and 37 that suppress amyloid fibril formation, plus a C20 fatty diacid that binds serum albumin and extends its circulating half-life. Cagrilintide is sold for research use only and is not approved for human or veterinary use.

What is cagrilintide used for in research?

Cagrilintide is used in research to study amylin receptor pharmacology across the AMY1, AMY2, and AMY3 receptor subtypes, calcitonin receptor cross-activity, hindbrain and hypothalamic feeding circuits, gastric emptying rate, and energy-balance endpoints in preclinical metabolic models. Its extended half-life makes it a practical tool for chronic-exposure study designs that native amylin cannot support. It is sold for research use only and is not approved for human or veterinary use.

What is the cagrilintide mechanism of action?

Cagrilintide is a non-selective amylin receptor agonist. Amylin receptors are heterodimers formed from a calcitonin receptor core paired with receptor activity-modifying protein 1, 2, or 3, producing the AMY1, AMY2, and AMY3 subtypes. Cagrilintide activates all three and retains activity at the calcitonin receptor itself. These receptors are densely expressed in the area postrema, nucleus tractus solitarius, and hypothalamus.

How does cagrilintide differ from native amylin?

Two engineered changes separate them. Substitutions at positions 14, 17, and 37 suppress the amyloid fibril formation that makes native human amylin difficult to formulate, and acylation with an eicosanedioic (C20) diacid through a gamma glutamic acid linker creates reversible albumin binding. Native amylin clears in roughly 13 minutes, while cagrilintide's reported elimination half-life falls near 159 to 195 hours. Receptor pharmacology is broadly preserved.

What is the molecular weight and CAS number of cagrilintide?

Cagrilintide has a CAS number of 1415456-99-3 and an approximate molecular weight of 4409 g/mol. It is a 37 residue acylated peptide supplied as a white lyophilized powder. Batch identity is confirmed by mass spectrometry against that target mass, and purity is verified at greater than or equal to 99% by reverse-phase HPLC.

How should cagrilintide be stored and reconstituted?

Lyophilized cagrilintide should be stored at -20°C, desiccated, and protected from light. For laboratory use it is soluble in sterile water or bacteriostatic water. Reconstituted material is generally kept refrigerated and protected from repeated freeze-thaw cycles, which degrade acylated peptides. Storage and handling protocols are determined by the receiving laboratory. This product is not intended for human or animal use.

Is VivePeptides cagrilintide third-party tested?

Yes. Every batch of cagrilintide is verified at greater than or equal to 99% purity by reverse-phase HPLC and confirmed by mass spectrometry, with independent analytical testing performed in United States laboratories. Certificates of analysis are available. All VivePeptides products are supplied strictly for laboratory research and are not for human or veterinary use.

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Cagrilintide

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