SNAP-8

99%+ Purity USA Tested

Research Use Only. Not for Human or Veterinary Use

SNAP-8: Synthetic octapeptide, CAS 868844-74-0, MW 876.01 g/mol, ≥99% purity. Lyophilized powder for laboratory use.

$90.00

20 in stock

Peptide Name	SNAP-8 (Acetyl Octapeptide-3)
CAS Number	868844-74-0
Molecular Formula	C₄₁H₆₅N₉O₁₂
Molecular Weight	876.01 g/mol
Sequence	Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH₂
Appearance	White lyophilized powder
Purity	≥99% (HPLC)
Storage	-20°C, desiccated, protected from light
Solubility	Soluble in sterile water

This product is not intended for human or animal use. For scientific research only.

VivePeptides provides detailed analytical results including High-Performance Liquid Chromatography (HPLC) and mass spectrometry data for all peptides. These reports confirm peptide purity, composition, and molecular accuracy, giving researchers full transparency and confidence in the materials used for their studies.

VivePeptides peptides should be stored in a cool, dry environment and protected from light and moisture. Lyophilized peptides are best kept refrigerated or frozen until use to maintain stability. Once reconstituted for research purposes, peptides should be stored according to standard laboratory protocols, typically under refrigeration, and handled using proper aseptic techniques to preserve integrity throughout the study period.

OVERVIEW

What Is SNAP-8 Peptide?

SNAP-8, also known as acetyl octapeptide-3, is a synthetic eight-amino acid peptide designed as an extension and enhancement of the hexapeptide Argireline (acetyl hexapeptide-3). The SNAP-8 peptide was developed to mimic a portion of the SNAP-25 protein (Synaptosomal-Associated Protein of 25 kDa), which plays a critical role in the SNARE complex responsible for neurotransmitter vesicle fusion and release at neuromuscular junctions.

SNAP-8 anti-wrinkle research has established it as one of the leading cosmeceutical research peptides in the scientific literature. The SNAP-8 acetyl octapeptide-3 sequence was designed to competitively interfere with SNARE complex assembly, potentially modulating neuromuscular signaling in research models. This mechanism has made SNAP-8 research particularly relevant to laboratories investigating skin biology, neuromuscular junction function, and the molecular basis of expression line formation. When researchers buy SNAP-8 from VivePeptides, they receive SNAP-8 99% purity compound from a trusted USA supplier.

SNARE Complex Modulator

Synthetic octapeptide mimicking SNAP-25 protein for neuromuscular research

≥99% HPLC Purity

Every batch verified via high-performance liquid chromatography

USA Tested & Verified

Third-party analytical testing performed in USA laboratories

RESEARCH

SNAP-8 Mechanism of Action in Research

The SNAP-8 mechanism of action is based on competitive inhibition of the SNARE complex, the molecular machinery responsible for synaptic vesicle fusion. SNAP-8 research has characterized how this peptide interacts with the neurotransmitter release apparatus at the molecular level.

SNARE Complex Competition

The SNARE (Soluble N-ethylmaleimide-sensitive factor Attachment protein REceptor) complex consists of three proteins: SNAP-25, syntaxin, and VAMP/synaptobrevin. SNAP-8 research demonstrates that the peptide acts as a competitive inhibitor by mimicking the N-terminal domain of SNAP-25, potentially interfering with SNARE complex assembly. By competing for binding interactions within the complex, SNAP-8 may modulate vesicle fusion efficiency and neurotransmitter release in research models.

Neuromuscular Junction Modulation

In laboratory models, SNAP-8 anti-wrinkle research has documented the peptide’s effects on neuromuscular junction signaling. Studies indicate that SNAP-8 may reduce the efficiency of acetylcholine release at the neuromuscular junction, potentially decreasing muscle contraction intensity in cell culture and ex vivo models. This proposed mechanism underlies the peptide’s classification as an anti-wrinkle research compound.

Dose-Response Characteristics

Published SNAP-8 research has characterized dose-response relationships in various in vitro assays. Studies indicate that SNAP-8 demonstrates concentration-dependent effects on SNARE complex formation and vesicle fusion, with measurable activity at micromolar concentrations in cell-based assays. —

COMPARISON

SNAP-8 vs Argireline: Anti-Wrinkle Peptide Research Comparison

SNAP-8 vs Argireline is one of the most common comparisons in cosmeceutical peptide research. Both target the SNARE complex but differ in structure, potency, and research profile.

Feature	SNAP-8 (Acetyl Octapeptide-3)	Argireline (Acetyl Hexapeptide-3)
CAS Number	868844-74-0	616204-22-9
Amino Acids	8	6
Molecular Weight	1075.16 Da	888.95 Da
Target	SNARE complex (SNAP-25 N-terminal mimic)	SNARE complex (SNAP-25 mimic)
Sequence Coverage	Extended SNAP-25 fragment	Shorter SNAP-25 fragment
Research Potency	Enhanced activity in comparative studies	Established baseline activity
Development	Second-generation (extended from Argireline)	First-generation SNARE-targeting peptide
Literature Volume	Growing research base	Extensively published

SNAP-8 was specifically designed as an improved version of Argireline, with the additional two amino acids potentially enhancing its interaction with the SNARE complex. Published comparative studies suggest SNAP-8 may demonstrate enhanced activity in certain in vitro assay systems. Both peptides are available from VivePeptides at research grade purity.

RESEARCH STUDIES

SNAP-8 Research Applications & Published Studies

SNAP-8 research spans cosmeceutical science, neurobiology, and molecular pharmacology, with studies examining its effects on SNARE complex dynamics and neuromuscular signaling.

SNARE Complex and Vesicle Fusion Research

Published SNAP-8 research has examined its effects on SNARE complex assembly using biochemical assays, including pull-down experiments and vesicle fusion reconstitution systems. Studies by Lipotec (the developing laboratory) documented SNAP-8’s ability to compete with native SNAP-25 for incorporation into the SNARE complex, with measurable reductions in complex formation at research-relevant concentrations.

Skin Biology Applications

SNAP-8 anti-wrinkle research includes in vitro studies using fibroblast and keratinocyte cell cultures, as well as ex vivo skin model systems. Published data have documented SNAP-8’s effects on markers of skin aging, collagen expression, and muscle cell contraction in laboratory settings. Blanes-Mira et al. (International Journal of Cosmetic Science, 2002) published foundational research on SNARE-targeting peptides in dermatological research applications.

Comparative Peptide Studies

SNAP-8 research includes head-to-head comparisons with Argireline and other SNARE-targeting peptides. These comparative studies help researchers understand structure-activity relationships within this peptide class and select the optimal compound for their specific experimental requirements.

QUALITY ASSURANCE

Quality & Testing Standards

HPLC & Mass Spectrometry

Every SNAP-8 batch undergoes HPLC and mass spectrometry analysis to verify peptide identity, sequence, and purity.

Third-Party Verified

All SNAP-8 is independently tested at third-party USA-based analytical laboratories with full documentation.

≥99% Purity Standard

VivePeptides SNAP-8 consistently meets or exceeds ≥99% purity for reliable cosmeceutical research.

FAQ

Frequently Asked Questions About SNAP-8

What is SNAP-8 used for in research?

SNAP-8 is used in preclinical research to study SNARE complex dynamics, neuromuscular junction signaling, synaptic vesicle fusion, and skin aging biology. It is a key compound in cosmeceutical peptide research. SNAP-8 is sold for research use only.

What purity is VivePeptides SNAP-8?

VivePeptides SNAP-8 acetyl octapeptide-3 is manufactured to ≥99% purity as verified by HPLC. Each batch is independently tested at USA-based analytical laboratories.

How should SNAP-8 be stored?

Lyophilized SNAP-8 should be stored at -20°C, protected from light and moisture. Reconstituted solutions should be stored at 2–8°C and used within 14 days. SNAP-8 contains a methionine residue; protect from oxidation.

How does SNAP-8 differ from Argireline in research?

SNAP-8 is an eight-amino acid extension of Argireline (six amino acids), both targeting the SNARE complex. The additional two residues in SNAP-8 were designed to enhance interaction with the SNAP-25 binding domain, and comparative research suggests SNAP-8 may demonstrate improved activity in certain in vitro assays.

Is VivePeptides SNAP-8 third-party tested?

Yes. Every lot of VivePeptides SNAP-8 undergoes independent third-party testing at USA-based laboratories, including HPLC purity analysis and mass spectrometry identity confirmation. Results are available for qualified researchers.

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